We are developing the Neurological Disease Ontology (ND) to provide a framework to enable representation of aspects of neurological diseases that are relevant to their treatment and study. ND is a representational tool that addresses the need for unambiguous annotation, storage, and retrieval of data associated with the treatment and study of neurological diseases. ND is being developed in compliance with the Open Biomedical Ontology Foundry principles and builds upon the paradigm established by the Ontology for General Medical Science (OGMS) (...) for the representation of entities in the domain of disease and medical practice. Initial applications of ND will include the annotation and analysis of large data sets and patient records for Alzheimer’s disease, multiple sclerosis, and stroke. (shrink)

Computer simulations show that an unstructured neural-network model [Shultz, T. R., & Bale, A. C. (2001). Infancy, 2, 501–536] covers the essential features␣of infant learning of simple grammars in an artificial language [Marcus, G. F., Vijayan, S., Bandi Rao, S., & Vishton, P. M. (1999). Science, 283, 77–80], and generalizes to examples both outside and inside of the range of training sentences. Knowledge-representation analyses confirm that these networks discover that duplicate words in the sentences are nearly identical and that (...) they use this near-identity relation to distinguish sentences that are consistent or inconsistent with a familiar grammar. Recent simulations that were claimed to show that this model did not really learn these grammars [Vilcu, M., & Hadley, R. F. (2005). Minds and Machines, 15, 359–382] confounded syntactic types with speech sounds and did not perform standard statistical tests of results. (shrink)

Metaphysics and language: Quine, W. V. O. On the individuation of attributes. Körner, S. On some relations between logic and metaphysics. Marcus, R. B. Does the principle of substitutivity rest on a mistake? Van Fraassen, B. C. Platonism's pyrrhic victory. Martin, R. M. On some prepositional relations. Kearns, J. T. Sentences and propositions.--Basic and combinatorial logic: Orgass, R. J. Extended basic logic and ordinal numbers. Curry, H. B. Representation of Markov algorithms by combinators.--Implication and consistency: Anderson, A. R. Fitch (...) on consistency. Belnap, N. D., Jr. Grammatical propaedeutic. Thomason, R. H. Decidability in the logic of conditionals. Myhill, J. Levels of implication.--Deontic, epistemic, and erotetic logic: Bacon, J. Belief as relative knowledge. Wu, K. J. Believing and disbelieving. Kordig, C. R. Relativized deontic modalities. Harrah, D. A system for erotetic sentences. (shrink)

In this chapter the intellectual-ecclesiastical context of religious philosophizing in Scotland in the second half of the nineteenth century is briefly sketched, and a selection of thinkers who followed in the wake of Reid’s common sense realism is introduced—Hamilton, Campbell Fraser and Flint among them. Responses to past philosophers and to then current trends in philosophy are reviewed. At a time when classical theistic arguments could no longer serve as once they had; when the ‘evidences’ of miracle and prophecy were (...) increasingly deemed suspect; and when evolutionary thought required a response, apologetic questions occupied such writers as Iverach and Bruce and Mackintosh. None of the philosophers here discussed could finally keep theology at bay. (shrink)

The Y‐box proteins are the most evolutionarily conserved nucleic acid binding proteins yet defined in bacteria, plants and animals. The central nucleic acid binding domain of the vertebrate proteins is 43% identical to a 70‐amino‐acid‐long protein (CS7.4) from E. coli. The structure of this domain consists of an antiparallel fivestranded β‐barrel that recognizes both DNA and RNA. The diverse biological roles of these Y‐box proteins range from the control of the E. coli cold‐shock stress response to the translational masking of (...) messenger RNA in vertebrate gametes. This review discusses the organization of the prokaryotic and eukaryotic Y‐box proteins, how they interact with nucleic acids, and their biological roles, both proven and potential. (shrink)

Economic approaches to both social evaluation and decision-making are typically Paretian or utilitarian in nature and so display commitments to both welfarism and consequentialism. The contrast between the economic approach and any rights-based social philosophy has spawned a large literature that may be divided into two branches. The first is concerned with the compatibility of rights and utilitarianism seen as independent moral forces. This branch of the literature may be characterized as an example of the broader debate between the teleological (...) and deontological approaches. The second is concerned with the possibility that substantial rights may be grounded in utilitarianism with the moral force of rights being derived from more basic commitments to welfarism and consequentialism. This branch of the literature may be characterized as an exploration of the flexibility of the teleological approach, and, in particular, its ability to give rise to views more normally associated with the deontological approach. This essay is concerned with the second branch of the literature. (shrink)

Knockout experiments in Tetrahymena show that linker histone H1 is not essential for nuclear assembly or cell viability. These results, together with a series of biochemical and cell biological observations, challenge the existing paradigm that requires linker histones to be a key organizing component of higher‐order chromatin structure. The H1 Knockouts also reveal a much more subtle role for H1. Instead of acting as a general transcriptional repressor, H1 is found to regulate a limited number of specific genes. Surprisingly, H1 (...) can both activate and repress transcription. We discuss how this architectural protein might accomplish this important regulatory role. (shrink)

Based upon a study of Mill's intellectual environment, life, critics contemporary and subsequent, and the relation of his religious writings to the rest of his corpus, Alan Sell presents an invaluable introduction to, and exploration of, Mill's religious thought.